The multifactorial emergence of the association between mortality and major risk factors of cardiovascular disease is not clearly established. Diverse countries have been monitoring and evaluating mortality and risk factors associated with cardiovascular disease as the levels and trajectories undergo continuous changes. Understanding the combined impacts of these alterations are crucial in taking precautionary measures in counteracting and managing cardiovascular disease. Mortality and risk factor data have been applied expansively for the monitoring and evaluation of cardiovascular disease issues and the spatiotemporal variations across populations. There are extant inequitable distribution of resources in the disparate regions and populations around the world in the quantification and analysis of the mortality, morbidity, risk factors or determinants of cardiovascular disease. The diagnosis of cardiovascular disease tends to be devoid of diagnostic tests of high specificity and sensitivity in certain instances. Poor diet is a leading etiologic factor of suboptimal health in cardiovascular disease. Diet, nutrition and scientific policy measures have accelerated, resulting in ambiguities, and also creating opportunities to obviate the excruciating health and economic burden in cardiovascular disease and other cardiometabolic disorders in vulnerable populations. These indicate that expansive spatiotemporal variations in the incidence between populations are attributable to inter alia certain contradictions in the modalities of event ascertainment, culture, and economic burden. This paper enhances and introduces novel issues, challenges and opportunities in the ecological presentations of the association between mortality and determinants or risk factors of cardiovascular disease.