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Original Research ArticlesPeer-reviewedOpen Access · CC BY 4.0

Detection of Candida albicans in the screening of cervical cancer in rural population of Lucknow

Detection of Candida albicans in the screening of cervical cancer

Jata Shankar Misra1, Srivastava Anand N2, Zaidi Zeeshan H3, Singh Shivani4

  1. 1 Cytologist, Department of Pathology, Era's Lucknow Medical College and Hospital, Era University, Lucknow (corresponding author)
  2. 2 Director Research, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India
  3. 3 Assist Professor, Department of Community Medicine, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India
  4. 4 Research Assistant, Department of Pathology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India

DOI: 10.31878/ijcbr.2021.74.01 · Published 2021-12-13 · pp. 1-5

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Abstract

Background

Study of Candidal infection is very essential in rural women who being illiterate and financially weak are not aware of personal genital hygiene and thus harbour persistent vaginal infections due to poor availability of medical amenities.

Method

Rural cervical cancer screening is in progress in the western region of Lucknow, India since May 2013 through camp approach and till date, a total of 2949 women have been cytologically examined. Candidal infection has been observed in the 143 cervical smears of women and  findings have been analyzed in relation to the different predisposing factor of cervical carcinogenesis.

Result

The incidence of Candida albicans seen in cervical smears of the total 2949 women examined was found to be 4.8% which is much higher than in their urban counterparts (1.2%). The Candida was seen more in the inflammatory smears (9.4%) and those showing squamous intraepithelial lesions of cervix (SIL). –  (8.2%). The fungus was found more prevalent in the reproductive age group and women complaining of vaginal discharge and was result of persistent vaginal infections in the rural women which should be treated.  The Candida was commonly seen in erosion cervix cases but its incidence was high in women with cervicitis and cervix bleeds on touch.

Conclusions

This persistent  vaginal infections were seen in the illiterate and poor rural women who are not aware of personal genital hygiene. There is a need to create awareness for personal genital hygiene through health workers for making any cancer screening program meaningful and successful.

Keywords: Candidal infection, Reproductive age, Vaginal discharge, Erosion cervix, Inflammatory smears

References

  1. References [Crossref] [Google Scholar]
  2. Spampinato C, Leonardi D. Candida infections, causes, targets and resistance mechanism: Traditional and alternative antifungal agents. BioMed Research Int. 2013; Article Id- 204237, 13 pages. [Crossref] [Google Scholar]
  3. Tripathi N, Kadam YR, Dhobale RV, Gore AD. Barriers for early detection of cancer amongst Indian rural women. South Asian J Cancer. 2014;3:122–7. [Crossref] [Google Scholar]
  4. Misra J.S, Srivastava A.N, Gupta H.P. Impact Of Literacy Status On The Cervical Cancer Screening In Rural Women Of India. Invest. Obstet. and Gynec. Res. 2017;6:45-49. [Crossref] [Google Scholar]
  5. Nayar R, Wilbur DC. The pap test and bethesda 2014. Acta Cytologica. 2015;59:121-32. [Crossref] [Google Scholar]
  6. Misra JS, Srivastava AN. Singh U Risk factors and strategies for control of carcinoma cervix in India: Hospital based cytological screening of 35 years. Ind J Cancer. 2009;46(2):155–9 [Crossref] [Google Scholar]
  7. Fule SR, Fule RP, Tankhiwale S. Clinical and laboratory evidence of Trichomonas vaginalis infections among women of reproductive age in rural area. Indian J Med Microbiol. 2012;30:314-18. [Crossref] [Google Scholar]
  8. Bukhari MH, Majeed M, Qamar S, Niazi S, Syed SZ, Yusuf AW, et al. Clinicopathological study of Papanicolau (Pap) smears for diagnosis of cervical infections. Diagn Cytopathol. 2012;40:35-41 [Crossref] [Google Scholar]
  9. Barouti E, Farzoneh F, Sene AA, Tajik Z, Jafari B. The pathogenic microorganisms in Papanicolau vaginal smears and correlation with inflammation. J Family Reprod Health. 2013;7:23-27. [Crossref] [Google Scholar]
  10. Guduco N, Gonene G, Isci H, Yigiter AB, Bassullu N, Dunder I. Clinical importance of detection of Bacterial vaginosis, Trichomonas vaginalis, Candida albicans and Actinomyces in Papanicolau smears. Clin Exp Obstet Gynaecol. 2012;39:333-36. [Crossref] [Google Scholar]
  11. Dalie F, Watchler B, L’oliver C, Holland G, Bannert G, Wilson D, et al. Cellular interaction of Candida albicans with human oral epithelial cells and enterocytes. Cell Microviol. 2010:12:248-71. [Crossref] [Google Scholar]
  12. Mayer P, Wilson G, Huba B. Candida albicans: Pathogenecity mechanisms. Virulence. 2013;4:119-28. [Crossref] [Google Scholar]
  13. Wohlmaster D, Vianna DRB, Heifer VE, Gimervas F, Consolan MEL, Barcello, RB, et al. Association of human Papillomavirus infection and Chlamydia trachomatis with intraepithelial alterations in cervical samples. Mem Inst Oswalw Reode Janso. 2016;11(2):186. [Crossref] [Google Scholar]
  14. Masand DL, Patel J, Gupta S. Utility of microbiological profile of symptomatic vaginal discharge in rural women of reproductive age group. J Clin Diag Res. 2015;9:QC04-07 [Crossref] [Google Scholar]