Skip to content
IJCBR|ISSN: 2521-0394
Log in
IJ
IJCBR
Case ReportsPeer-reviewedOpen Access · CC BY 4.0

Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report

Rajkumar Chauhan1, Pranav Chadha2, Kaustav Talapatra3, Santanu Sen4, Sameer Tulpule5, Mayuresh D. Virkar6, Amrita Shrivastava7, Reuben Jake Rodrigues8

  1. 1 RSO, Medical Physicist, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  2. 2 Head of the Unit, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India (corresponding author)
  3. 3 Head of the Department, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  4. 4 Consultant, Haematology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
  5. 5 Consultant, Haematology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
  6. 6 Clinical Associates, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  7. 7 DMRT, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
  8. 8 Medical Officer, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai.

DOI: 10.31878/ijcbr.2020.64.06 · Published 2020-10-29 · pp. 25-28

Download PDF

Abstract

Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.

Keywords: Hematopoietic Stem Cell Transplantation; Graft-versus-Host Disease; Thalassemia Minor;, Radiotherapy; Myeloablative conditioning; Haemoglobinopathies