ORAL PEMPHIGUS – A CASE REPORT

Authors: KUNDANA INDUPURU, KEERTHANA K L, RAM KUMAR TIRANDAS, K SOWJANYA, C MOUNIJA.

Int J Clin and Biomed Res 2015; 1 (4): 62-65.

PEMPHIGUS is a serious chronic skin disease characterized by the appearance of vesicles & bullae, small or large fluid filled blisters that develop in cycles. The term pemphigus refers to a group of autoimmune blistering diseases of skin and mucous membranes that are characterized histologically by intraepidermal blisters due to acantholysis and immunopathologically by an in vivo bound & circulating IgG directed against the cell surface of keratinocytes. Pemphigus vulgaris is the most common form and frequently affects oral cavity. Main antigen is Dsg 3 (desmoglein) but 50% of patients also have autoantibodies to Dsg 1. Dsg 3: Dsg 1 is directly proportional to severity. We present a case of pemphigus occurring in the oral cavity of a 45-year-old male. Treatment with oral prednisolone and topical steroid resulted in remission of the disease. Clinical features, histological features and treatment of pemphigus vulgaris will be discussed.

KEYWORDS: Pemphigus, blisters, acantholysis, autoantibodies.



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